[PDF][PDF] The pathobiology of vascular dementia

C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Recent developments in understanding brain aging: implications for Alzheimer's disease and vascular cognitive impairment

F Deak, WM Freeman, Z Ungvari… - … Series A: Biomedical …, 2016 - academic.oup.com
As the population of the Western world is aging, there is increasing awareness of age-
related impairments in cognitive function and a rising interest in finding novel approaches to …

Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment

C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Vascular aspects of cognitive impairment and dementia

M Wiesmann, AJ Kiliaan… - Journal of Cerebral …, 2013 - journals.sagepub.com
Hypertension and stroke are highly prevalent risk factors for cognitive impairment and
dementia. Alzheimer's disease (AD) and vascular dementia (VaD) are the most common …

[HTML][HTML] Hypertension, brain damage and cognitive decline

D Gąsecki, M Kwarciany, W Nyka… - Current hypertension …, 2013 - Springer
Loss of cognitive function is one the most devastating manifestations of ageing and vascular
disease. Cognitive decline is rapidly becoming an important cause of disability worldwide …

The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease

TL Bailey, CB Rivara, AB Rocher, PR Hof - Neurological research, 2004 - Taylor & Francis
Age-related and amyloid-induced pathology of the cerebral microvasculature have been
implicated as potential contributing factors to the pathogenesis of Alzheimer's disease (AD) …

The vascular component of Alzheimer's disease

D Fior Muresanu, A Popa-Wagner… - Current …, 2014 - ingentaconnect.com
Cognitive abilities depend primarily on cerebrovascular health and aging. In this work, we
examine the pathogenic mechanisms of brain dysfunction linked to vascular risk factors …

[HTML][HTML] Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Q Yang, X Wei, B Deng, Z Chang, D Jin, Y Huang… - Neurobiology of …, 2022 - Elsevier
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

[HTML][HTML] Diagnosis and treatment of vascular damage in dementia

GJ Biessels - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
This paper provides an overview of cognitive impairment due to vascular brain damage,
which is referred to as vascular cognitive impairment (VCI). Over the past decades, we have …

Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia

RO Akinyemi, EB Mukaetova-Ladinska… - Current Alzheimer …, 2013 - ingentaconnect.com
Age is the strongest risk factor for brain degeneration whether it results from vascular or
neurodegenerative mechanisms or both. To evaluate the current views on the impact of …