DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …

Molecular profiling of cancer at the transcript level has become routine. Large-scale analysis
of proteomic alterations during cancer progression has been a more daunting task. Here, we …

To understand functional consequences of genetic and transcriptional aberrations in
prostate cancer, the proteomic changes during disease formation and progression need to …

To catalog protein-altering mutations that may drive the development of prostate cancers
and their progression to metastatic disease systematically, we performed whole-exome …

Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …

Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …

Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …

Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …

Comprehensive genomic characterization of prostate cancer has identified recurrent
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …

Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …