The radiation-induced bystander effect (RIBE) can increase cellular toxicity in a gap junction
dependent manner in unirradiated bystander cells. Recent reports have suggested that …

Gap junctions propagate toxic effects among tumor cells during chemotherapy, but could
also enhance killing of normal cells by the same mechanism. We show that the effect of gap …

Previous work has shown that gap junction intercellular communication (GJIC) enhances
cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular cells. In …

Bi-directional signaling involved in radiation-induced bystander effect (RIBE) between
irradiated carcinoma cells and their surrounding non-irradiated normal cells is relevant to …

Our understanding of how radiation kills normal and tumour cells has been based on an
intimate knowledge of the direct induction of DNA damage and its cellular consequences …

Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA
and induce apoptosis. However, increasing reports of side effects and drug resistance …

Cisplatin-induced cell death can be triggered by cell-to-cell communication through gap
junctions. Here, we show that activated src produces tyrosine phosphorylation of the gap …

Most of the studies of radiation-induced bystander effects (RIBE) have been focused on
understanding the radiobiological changes observed in bystander cells in response to the …

Drug resistance limits the clinical application of cisplatin, a widely used chemotherapeutic
agent. Gap junction (GJ) is a channel that enhances cytotoxicity of certain chemotherapeutic …

It is controversially discussed that irradiation induces bystander effects via gap junction
channels and/or diffusible cellular factors such as nitric oxide or cytokines excreted from the …