with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …

Objective—The role of inorganic phosphate in the pathogenesis of vascular calcification
(VC) has been studied extensively in recent years. Phosphonoformic acid (PFA), an inhibitor …

Vascular calcification is associated with increased cardiovascular morbidity and mortality. A
number of calcification inhibitors have been defined recently, including inorganic …

In bone and teeth formation, coordinated calcification is a highly desirable biological
process. However, heterotopic calcification at unwanted tissue sites leads to dysfunction …

Vascular calcification is prevalent in aging as well as a number of pathological conditions,
and it is now recognized as a strong predictor of cardiovascular events in the general …

Vascular calcification is highly prevalent and, when present, is associated with major
adverse cardiovascular events. Vascular smooth muscle cells play an integral role in …

Vascular calcification is highly correlated with cardiovascular disease (CVD) and is a
significant predictor of cardiovascular events, especially in high risk patients such as the end …

Cardiovascular disease begins early in the course of renal decline and is a life-limiting
problem in patients with CKD. The increased burden of cardiovascular disease is due, at …

Vascular calcification is related to vascular diseases, for example, atherosclerosis, and its
comorbidities, such as diabetes and chronic kidney disease. In each condition, a distinctive …

The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by
calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed …