Ankylosing spondylitis (AS) is a highly heritable disease for which there is a great unmet
need for improved therapies. Genetics research has identified several major pathways …

Genome-wide association studies (GWAS) have identified 113 single nucleotide
polymorphisms (SNPs) affecting the risk of developing ankylosing spondylitis (AS), and an …

Ankylosing spondylitis (AS) is the prototypic form of axial spondyloarthritis (axSpA). It is
highly heritable, with studies conducted in twins and in unrelated cases and controls …

Ankylosing spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex
polygenic aetiology. Genome-wide association studies have identified more than 100 loci …

The findings suggest that further genome-wide studies in large case–control cohorts are
likely to be very productive in this disease. The IL23R findings and subsequent …

Ankylosing spondylitis is an insidiously progressive and debilitating form of arthritis involving
the axial skeleton. The long delay in diagnosis and insufficient response to currently …

Ankylosing spondylitis (AS) is a common immune‐mediated inflammatory arthritis with a
strong genetic predisposition. We review recent data from genetic and animal studies …

Background Ankylosing spondylitis (AS) is a complex condition with a significant genetic
component. This study explored circulating proteins as potential genetic drug targets or …

Ankylosing spondylitis (AS) is a complex disease involving multiple risk factors, both genetic
and environmental. AS patients are predominantly young men, and the disease is …

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthropathy. In
addition to being strongly associated with HLA-B27, a further 13 genes have been robustly …