This paper reviews our present knowledge on the contribution of ceramide (Cer),
sphingomyelin (SM), dihydroceramide (DhCer) and sphingosine-1-phosphate (S1P) in …

Metabolic syndrome is nosographically defined by using clinical diagnostic criteria such as
those of the International Diabetes Federation (IDF) ones, including visceral adiposity, blood …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Objective: Recent studies indicate that sphingolipids, sphingomyelin (SM) and ceramide
(Cer) are associated with the development of metabolic syndrome. However, detailed …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:
1, 18: 0 sphingoid backbone, C 14-C 26 N-acyl part) of" normal" sphingolipid levels in …

The increasing prevalence of obesity and metabolic diseases is a worldwide public health
concern, and the advent of new analytical technologies has made it possible to highlight the …

Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging
health crisis in Western nations. Although the symptoms and clinical pathology and …

Sphingolipids are structural components of cell membranes and lipoproteins but also act as
signaling molecules in many pathophysiological processes. Although sphingolipids …

Nutrient oversupply associated with a high fat diet (HFD) significantly alters cellular
metabolism, and specifically including sphingolipid metabolism. Sphingolipids are emerging …