Chemical insights into the issues of Gd retention in the brain and other tissues upon the administration of Gd‐containing MRI contrast agents

E Gianolio, ED Gregorio, S Aime - European Journal of …, 2019 - Wiley Online Library
Gadolinium bearing contrast agents (GBCA) are commonly used in clinical settings as they
add relevant physiological information to the superb anatomical resolution of the MR …

The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists

M Le Fur, P Caravan - Metallomics, 2019 - academic.oup.com
Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic
resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually …

Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents: comparative …

T Frenzel, C Apte, G Jost, L Schöckel… - Investigative …, 2017 - journals.lww.com
Objective Multiple clinical and preclinical studies have reported a signal intensity increase
and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based …

Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents

S Fingerhut, AC Niehoff, M Sperling, A Jeibmann… - Journal of Trace …, 2018 - Elsevier
Due to its paramagnetic properties resulting from seven unpaired f-electrons, Gd is
frequently applied in magnetic resonance imaging examinations. Due to the acute toxicity of …

Speciation analysis of gadolinium in the water-insoluble rat brain fraction after administration of gadolinium-based contrast agents

I Strzeminska, C Factor, P Robert, J Szpunar… - Investigative …, 2021 - journals.lww.com
Purpose To date, the analysis of gadolinium (Gd) speciation in the brain of animals
administered with macrocyclic and linear Gd-based contrast agents (GBCAs) has been …

Long-term evaluation of gadolinium retention in rat brain after single injection of a clinically relevant dose of gadolinium-based contrast agents

I Strzeminska, C Factor, P Robert, AL Grindel… - Investigative …, 2020 - journals.lww.com
Purpose The aim of this study was to investigate the presence and chemical forms of
residual gadolinium (Gd) in rat brain after a single dose of Gd-based contrast agent …

Distribution and chemical forms of gadolinium in the brain: a review

T Kanda, Y Nakai, A Hagiwara, H Oba… - The British journal of …, 2017 - academic.oup.com
In the 3 years since residual gadolinium-based contrast agent (GBCA) in the brain was first
reported, much has been learned about its accumulation, including the pathway of GBCA …

Gadolinium retention in the rat brain: assessment of the amounts of insoluble gadolinium-containing species and intact gadolinium complexes after repeated …

E Gianolio, P Bardini, F Arena, R Stefania… - Radiology, 2017 - pubs.rsna.org
Purpose To evaluate the speciation of gadolinium-containing species after multiple
administrations of the gadolinium-based contrast agents (GBCAs) gadodiamide and …

[HTML][HTML] Gadolinium deposition in the brain: another concern regarding gadolinium-based contrast agents

N Karabulut - Diagnostic and Interventional Radiology, 2015 - ncbi.nlm.nih.gov
Life is continuously confronting us with new issues and sometimes breaking our rou-tine.
One case in point is the curious way radiologists' knowledge about the benefits and risks of …

Gadolinium in medical imaging—usefulness, toxic reactions and possible countermeasures—A review

L Blomqvist, GF Nordberg, VM Nurchi, JO Aaseth - Biomolecules, 2022 - mdpi.com
Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation
(Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to …