Although Metformin, a first-line antidiabetic drug, can ameliorate ischemia/reperfusion (I/R)
induced brain damage, but how metformin benefits injured hippocampus and the …

Metformin (Met) is a commonly used drug in the treatment of type 2 diabetes. Currently, it
has been found that Met can effectively reduce the incidence of stroke and exert anti …

Traumatic brain injury (TBI) triggers a complex sequence of inflammatory responses that
contribute to secondary injury. Metformin, a first-line drug used to treat type 2 diabetes, is …

Sepsis-induced brain injuries increase mortality, morbidity, cognitive impairment and lack of
effective therapeutic treatment. Previous studies have suggested that metformin provides …

Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several
studies have reported that metformin can improve the prognosis of stroke patients and that …

Current studies demonstrated that metformin is not only a hypoglycemic drug, but also a
neuro-protective agent. However, the effect of metformin during ischemic brain injury is …

Here, we have investigated the effect of metformin pretreatment in the rat models of global
cerebral ischemia. Cerebral ischemia which leads to brain dysfunction is one of the main …

Global cerebral ischemia arises in patients who have a variety of clinical conditions
including cardiac arrest, shock and asphyxia. In spite of advances in understanding of the …

According to the previous research, metformin, a medication utilized for type 2 diabetes
management, inhibits neural aging and reduces infarct size by enhancing angiogenesis in a …

Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in
cerebral ischaemia. Objective This study examined pretreatment with metformin and …