Testosterone deficiency and the prostate

JP Alukal, H Lepor - Urologic Clinics, 2016 - urologic.theclinics.com
The prostate is a male reproductive organ of both endodermal and mesodermal origin; it is
located in the pelvis, immediately superior to the muscles of the pelvic floor. The prostate is …

Testosterone replacement therapy on the natural history of prostate disease

A Moore, MJ Butcher, TS Köhler - Current urology reports, 2015 - Springer
The physiology of testosterone production and action are closely related to prostatic
disease. An understanding of the natural history of testosterone and prostate growth and …

Testosterone therapy and prostate cancer: incorporating low-level evidence into practical recommendations

A Morales, DR Siemens - Urologic Clinics, 2022 - urologic.theclinics.com
In men's health 2 fields share the characteristics of being both controversial and involving
several medical disciplines: testosterone deficiency syndrome (TDS) and prostate cancer …

Testosterone and the prostate: implications for the treatment of hypogonadal men

JD Holyoak, ED Crawford, RB Meacham - Current urology reports, 2008 - Springer
Late-onset hypogonadism (LOH) and testosterone replacement therapy (TRT) are subjects
of much recent research. Because aging men are at risk for benign prostatic hyperplasia …

Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk

JE Michaud, KL Billups… - Therapeutic advances in …, 2015 - journals.sagepub.com
Testosterone plays a central role in male development and health. Likewise, androgen
deficiency, or hypogonadism, is associated with a variety of symptoms including decreased …

Updated review of testosterone replacement therapy in the setting of prostate cancer

M Polchert, I Voznesensky, A Soubra… - … Clinical Research and …, 2021 - liebertpub.com
Since the 1940s, elevated serum testosterone (T) levels have been infamously suggested as
a causal factor in the development of prostate cancer (PCa); this time was also the dawn of …

Differing levels of testosterone and the prostate: a physiological interplay

SL Goldenberg, A Koupparis, ME Robinson - Nature Reviews Urology, 2011 - nature.com
Abstract| The controversies surrounding testosterone replacement therapy (TRT) have been
addressed in the past few years. Although the androgenic effects of TRT on normal and …

Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?

IV Litvinov, AM De Marzo… - The Journal of Clinical …, 2003 - academic.oup.com
Multiple genetic changes are required to produce prostatic cancer cells that can metastasize
and kill the patient (1, 2). The most fundamental consequence of these molecular …

[PDF][PDF] Testosterone and prostate health: debunking myths demands evidence, caution, and good clinical judgment

A Morales - European urology, 2006 - Citeseer
The review article by Dr Morgentaler [1] on this highly controversial topic is a timely and
wellthought-out challenge to urologists worldwide. I very much admire his refreshing …

[引用][C] The prostate as an endocrine organ: androgens and estrogens

P Ekman - The Prostate, 2000 - Wiley Online Library
The prostate is an endocrine organ, dependent on testosterone to maintain its size and
secretory function. It atrophies after castration, but regains its normal characteristics …