Megakaryocytes (MKs) are rare hematopoietic cells in the adult bone marrow and produce
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …

Objectives Ex vivo engineered production of megakaryocytes (MKs) and platelets (PLTs)
from human pluripotent stem cells is an alternative approach to solve shortage of donor …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Platelets, derived from megakaryocytes, are anucleate cytoplasmic discs that circulate in the
blood stream and play major roles in hemostasis, inflammation, and vascular biology …

Human pluripotent stem cells [PSCs; including human embryonic stem cells (ESCs) and
induced pluripotent stem cells (iPSCs)] can infinitely proliferate in vitro and are easily …

Megakaryocytes (MKs) are the precursors of platelets (PLTs) and may be used for PLT
production in vivo or in vitro, as well as a source for PLT-derived growth factors. Induced …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …

Because of a lack of platelet supply and a US Food and Drug Administration-approved
platelet growth factor, megakaryocytes have emerged as an effective substitute for …

Platelets, the chief effector of hemostasis, are small anucleate blood cells generated from
megakaryocytes (MKs), and the defects in platelet production or function lead to a variety of …