Frontal lobe dysfunction is thought to be involved in schizophrenia and age-associated
cognitive decline. Frontal lobe volume changes have been investigated in these conditions …

Marijuana is the most widely used illicit substance in the United States; however, previous
imaging studies have not detected altered brain structure in marijuana users compared to …

Chronic smoking in alcohol dependence is associated with abnormalities in brain
morphology and metabolite levels in large lobar regions (eg frontal lobe). Here, we …

Methamphetamine (MA) is associated with behavioral and cognitive deficits that may be
related to macrostructural abnormalities. Quantitative anatomical comparisons between …

BACKGROUND: Alcohol use disorders (AUDs) are associated with smaller grey matter
volumes in cortical and subcortical brain regions which are related to cognitive impairments …

Context In alcohol-dependent patients, brain atrophy and functional brain activation elicited
by alcohol-associated stimuli may predict relapse. However, to date, the interaction between …

The structural effects of cocaine on neural systems mediating cognition and motivation are
not well known. By comparing the thickness of neocortical and paralimbic brain regions …

RATIONALE: Two previous studies have utilized diffusion tensor imaging (DTI) to examine
microstructural integrity in cocaine abuse and found evidence of brain abnormalities in white …

Numerous studies have documented cognitive impairments and hypoactivity in the
prefrontal and anterior cingulate cortices in drug users. However, the relationships between …

BACKGROUND: Reinforcement of behavioral responses involves a complex cerebral circuit
engaging specific neuronal networks that are modulated by cortical oversight systems …