Background: The antibacterial effect of antibiotics is linked to the free drug concentration.
This study investigated the applicability of an ultrafiltration method to determine free plasma …

The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill
patients is growing in popularity, although there are limited data describing the potential …

Objectives To describe the achievement of unbound β-lactam antibiotic concentration
targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the …

Background Only about 50% of intensive care unit (ICU) patients reach a free trough
concentration above MIC (100% fT> MIC) of beta-lactam antibiotics. Although dose …

Background Recent studies show that suboptimal blood levels of β-lactam antibiotics are
present in intensive care unit (ICU) patients. A common reference method for assessing drug …

Patients in the intensive care unit (ICU) are at risk for suboptimal levels of β-lactam
antibiotics, possibly leading to poor efficacy. Our aim was to investigate whether the actual …

Severe infection and sepsis are the most common causes of morbidity and mortality in non-
cardiac intensive care units worldwide [1]. Research has shown that initiating appropriate …

Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

There is strong evidence in literature supporting the benefit of monitoring plasma
concentrations of β-lactam antibiotics in the critically ill to ensure appropriateness of dosing …

Therapeutic drug monitoring (TDM) of antibiotics (ATB) in patients with serious bacterial
infections allows optimization of the efficacy of the treatment while reducing the risk of …