In critically ill patients there is extensive evidence of subtherapeutic antibiotic exposure from
standard doses across different antibiotic classes. This can be a direct consequence of …

In some patient groups, including critically ill patients, the pharmacokinetics of β-lactam
antibiotics may be profoundly disturbed due to pathophysiological changes in distribution …

Antibiotic (ATB) prescription in an intensive care unit (ICU) requires continuous monitoring of
serum dosages due to the patient's pathophysiological condition. Dosing adjustment is …

Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce …

Contemporary β-lactam antibiotic dosing is debatable in severely ill patients, since the
occurrence of pathophysiological changes in critical illness can result in great inter …

Plasma exchange (PE) is a treatment modality frequently used for many autoimmune
diseases and may cause extracorporeal elimination of antibiotics. No data currently exist on …

OBJECTIVE: β-lactams are the cornerstone of empiric and targeted antibiotic therapy for
critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug …

Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …

Therapeutic drug monitoring (TDM) of antibiotics is particularly important in populations with
high pharmacokinetic variabilities, such as critically ill patients, leading to unpredictable …

Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …