Due to their broad spectrum of activity and wide therapeutic index, β-lactam antibiotics (β-
LA) are commonly used to treat severe sepsis in critically ill patients in intensive care units …

Objectives Emerging evidence supports the use of therapeutic drug monitoring (TDM) of β-
lactams for intensive care unit (ICU) patients to optimize drug exposure, although limited …

A large variation in the levels of different ß‐lactams and other antibiotics used in critically ill
patients has been documented. The aim of this study is to establish and validate a fast, ultra …

The use of antibacterial drugs is very common in critically ill patients and beta-lactam agents
are widely used in this context. Critically ill patients show several characteristics (eg, sepsis …

Evaluation of dosing regimens for critically ill patients requires pharmacokinetic data in this
population. This prospective observational study aimed to describe the population …

Altered pharmacokinetics (PK) of hydrophilic antibiotics in critically ill patients is common,
with possible consequences for efficacy and resistance. We aimed to describe ceftazidime …

Editorial Musteata into free concentrations, the problem is exacerbated by the perceived
minor benefit from using them instead of total concentrations. Accordingly, research into free …

Background: enhanced methods of therapeutic drug monitoring are required to support the
individualisation of antibiotic dosing based on pharmacokinetics (PK) parameters. PK …

Introduction Therapeutic drug monitoring (TDM) is a useful tool to optimize antibiotic therapy.
Increasing interest in alternative dosing strategies of beta-lactam antibiotics, eg continuous …

Background Critically ill patients undergo extensive physiological alterations that will have
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …