Importance The prevalence of germline pathogenic variants (PVs) in cancer susceptibility
genes in US Black women compared with non-Hispanic White women with breast cancer is …

To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …

Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …

Methods| The Women's Health Initiative (WHI) is a prospective study of morbidity and
mortality that enrolled 161 808 postmenopausal women aged 50 to 79 years at 40 US sites …

Background The risks of breast cancer in African American (AA) women associated with
inherited mutations in breast cancer predisposition genes are not well defined. Thus …

PURPOSE The prevalence of germline pathogenic variants (PVs) in established breast
cancer predisposition genes in women in the general population over age 65 years is not …

PURPOSE Women with a family history of breast cancer are frequently referred for
hereditary cancer genetic testing, yet< 10% are found to have pathogenic variants in known …

Abstract Purpose of Review Despite a steady improvement in breast cancer survival rates
over the past several decades, mortality disparities remain among Black women, who have …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Importance To date, few studies have examined the extent to which polygenic single-
nucleotide variation (SNV)(formerly single-nucleotide polymorphism) scores modify risk for …