Objectives: Ventilator-induced lung injury has substantive impact on mortality of patients with
acute respiratory distress syndrome. Although low tidal volume ventilation has been shown …

Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

The concept that mechanical ventilation (MV) could produce lung injury was advanced
during the polio epidemic of the 1950s when it was noted that patients dying after prolonged …

Supporting this are the recent studies showing that a “lung-protective approach” by lowering
tidal volumes and/or recruiting collapsed lung is associated with increased survival rate [9 …

The clinical relevance of experimental ventilator-induced lung injury has recently received a
resounding illustration by the Acute Respiratory Distress Syndrome Network trial that …

Mechanical ventilation has been demonstrated to exacerbate lung injury, and a sufficiently
high tidal volume can induce injury in otherwise healthy lungs. However, it remains …

Previous animal studies have identified a role for activation of innate immunity in the
pathogenesis of ventilator-associated lung injury. These studies have used large tidal …

During mechanical ventilation, high end-inspiratory lung volume (whether it be because of
large tidal volume (VT) and/or high levels of positive end-expiratory pressure) results in a …

Objective Previous animal studies have shown that certain modes of mechanical ventilation
(MV) can injure the lungs. Most of those studies were performed with models that differ from …

Mechanical ventilation is an often life-saving treatment which unfortunately is not devoid of
risk. In recent years, extensive research has called the attention of physicians to the …