A growing body of literature has established the anabolic benefits of testosterone (T) therapy
in hypogonadal men. However, there remains a paucity of data regarding the risks of …

Androgens have been implicated in prostate tumourigenesis. However, no association
between circulating levels of androgens and prostate cancer risk was found in a recent large …

Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …

abstract Context: Concern exists that androgen treatment might adversely impact prostate
health in older men. Dihydrotestosterone (DHT), derived from local conversion of …

Androgen replacement therapy in the aging male with partial androgen deficiency improved
quality of life. However, such treatment is prohibited for men with a preexisting prostate …

Progress in the understanding of the action of exogenous testosterone has diminished many
of the concerns that existed regarding its safety. The major interest is now focused on the …

Due to late onset hypogonadism (LOH), there is an increased usage of testosterone
replacement therapy (TRT) in the aging male population. Since prostate is a target organ for …

Data from animal, clinical, and prevention studies support the role of androgen in prostate
cancer growth, proliferation, and progression. However, results serum-based epidemiologic …

CONTEXT: The traditional belief that prostate cancer (PCa) growth is dependent on serum
testosterone (T) level has been challenged by recent negative studies in noncastrated men …

Since in men androgen levels decrease with age and result in symptoms of hypogonadism,
the use of testosterone supplementation to treat symptoms resulting from hypogonadism is …