Epigenetic mechanisms including DNA methylation are critical regulators of organismal
development and tissue homeostasis. DNA methylation is the transfer of methyl groups to …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

Prostate development, benign hyperplasia and cancer involve androgen and growth factor
signaling as well as stromal–epithelial interactions. We review how DNA methylation …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

Prostate cancer is the most common malignancy and the second leading cause of cancer
death among men in the United States. There are three well-established risk factors for …

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

The prostate gland is the most common site of cancer and the second leading cause of
cancer death in American men. Recent emerging molecular biological technologies help us …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Background The prostate gland is the most common site of cancer and the second leading
cause of cancer mortality in American men. It is well known that epigenetic alterations such …

There is increasing evidence that DNA methylation is a critical source of gene regulation. In
addition, interindividual differences in DNA methylation status in cancer related genes are …