Highly active antiretroviral therapy-associated metabolic syndrome and lipodystrophy: Pathophysiology and current therapeutic interventions

S Nzuza, S Zondi, R Hurchund, PMO Owira - Journal of Endocrinology …, 2017 - jofem.org
The use of highly active antiretroviral therapy (HAART) has extremely enhanced the clinical
outcome of HIV disease with a decrease in mortality and morbidity. However, the inclusion of …

HIV-therapy associated lipodystrophy: experimental and clinical evidence for the pathogenesis and treatment

MV Stankov, GMN Behrens - Endocrine, Metabolic & Immune …, 2007 - ingentaconnect.com
The introduction of highly active antiretroviral therapy (HAART) including nucleoside reverse
transcriptase inhibitors (NRTI) and protease inhibitors (PI) has dramatically improved the …

Toxic metabolic syndrome associated with HAART

SB Haugaard - Expert opinion on drug metabolism & toxicology, 2006 - Taylor & Francis
Acquired fat redistribution, that is, peripheral fat loss often accompanied by central fat
accumulation in patients with HIV infection is the most common form of lipodystrophy in man …

[PDF][PDF] Metabolic syndrome

X Li, M Hsieh, S Chang - Insul Insistence Syndr ed, 2014 - researchgate.net
The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired
immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with …

Lipodystrophy and metabolic disorders as complication of antiretroviral therapy of HIV infection

A Holstein, A Plaschke… - Experimental and clinical …, 2001 - thieme-connect.com
Peripheral lipodystrophy, central adiposity, hyperlipidaemia, insulin resistance, and diabetes
mellitus, in varying constellations, are frequent complications of highly active antiretroviral …

Lipotoxicity on the basis of metabolic syndrome and lipodystrophy in HIV-1-infected patients under antiretroviral treatment

M Giralt, J Diaz-Delfin… - Current …, 2010 - ingentaconnect.com
The development of efficacious antiretroviral drugs that minimize adverse effects is a current
challenge in HIV-1 therapy. Metabolic alterations reminiscent of the metabolic syndrome and …

Therapy insight: body-shape changes and metabolic complications associated with HIV and highly active antiretroviral therapy

J Falutz - Nature Clinical Practice Endocrinology & Metabolism, 2007 - nature.com
Increasingly effective therapies for HIV infection are now available. These treatments,
referred to collectively as highly active antiretroviral therapy, comprise various combinations …

Approach to the human immunodeficiency virus-infected patient with lipodystrophy

TT Brown - The Journal of Clinical Endocrinology & Metabolism, 2008 - academic.oup.com
Subcutaneous atrophy and central fat accumulation are common among HIV-infected
patients receiving highly active antiretroviral therapy, and may be accompanied by …

Visceral fat as target of highly active antiretroviral therapy-associated metabolic syndrome

G Barbaro - Current pharmaceutical design, 2007 - ingentaconnect.com
HIV-associated lipodystrophy or lipoatrophy, unreported before the introduction of highly
active antiretroviral therapy (HAART), was first described in 1998, and has a prevalence …

Metabolic syndrome associated with HIV and highly active antiretroviral therapy

G Barbaro, G Iacobellis - Current diabetes reports, 2009 - Springer
The introduction of highly active antiretroviral therapy (HAART) has significantly improved
the clinical outcome of HIV disease with increased survival rates. However, some HAART …