[HTML][HTML] Multimodal analysis of central nervous system tumor tissue endogenous fluorescence with multiscale excitation

F Poulon, A Chalumeau, F Jamme, J Pallud… - Frontiers in …, 2018 - frontiersin.org
The primary therapeutic approach for high-grade brain tumor is surgical resection. However,
identifying tumor margins in vivo remains a major challenge. Biopsy analysis remains the …

[HTML][HTML] Quantitative Endogenous Fluorescence Analysis Discriminates Glioblastoma Tumor through Visible and NIR Excitation

H Mehidine, E Kaadou Mouawad, P Varlet, B Devaux… - Photonics, 2023 - mdpi.com
Nowadays, the ability to diagnose brain tumors intraoperatively and delineate their margins,
as accurately as possible, is of primordial importance during surgery. However, the exact …

Development of a new autofluorescence probe for the analysis of normal and tumour brain tissues

R Siebert, MHV Thi, F Jean, Y Charon… - … Solutions for Better …, 2008 - spiedigitallibrary.org
Fluorescence spectroscopy of endogenous emission of brain tumors, in particular
glioblastoma multiforme, will be used for intraoperative localization of brain tumor margins …

[HTML][HTML] Real-time Brain Tumor imaging with endogenous fluorophores: a diagnosis proof-of-concept study on fresh human samples

F Poulon, J Pallud, P Varlet, M Zanello, F Chretien… - Scientific reports, 2018 - nature.com
The primary line of therapy for high-grade brain tumor is surgical resection, however,
identifying tumor margins in vivo remains a major challenge. Despite the progress in …

[HTML][HTML] Intraoperative microscopic autofluorescence detection and characterization in brain tumors using stimulated Raman histology and two-photon fluorescence

G Fürtjes, D Reinecke, N von Spreckelsen… - Frontiers in …, 2023 - frontiersin.org
The intrinsic autofluorescence of biological tissues interferes with the detection of
fluorophores administered for fluorescence guidance, an emerging auxiliary technique in …

Time-resolved fluorescence spectroscopy of human brain tumors

L Marcu, RC Thompson, S Garde, M Sedrak… - Optical Biopsy …, 2002 - spiedigitallibrary.org
Fluorescence spectroscopy of the endogenous emission of brain tumors has been
researched as a potentially important method for the intraoperative localization of brain …

[HTML][HTML] Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy

WH Yong, PV Butte, BK Pikul, JA Jo… - … in bioscience: a …, 2006 - ncbi.nlm.nih.gov
Neuropathology frozen section diagnoses are difficult in part because of the small tissue
samples and the paucity of adjunctive rapid intraoperative stains. This study aims to explore …

[HTML][HTML] Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls

M Zanello, F Poulon, J Pallud, P Varlet, H Hamzeh… - Scientific reports, 2017 - nature.com
Delineating tumor margins as accurately as possible is of primordial importance in surgical
oncology: extent of resection is associated with survival but respect of healthy surrounding …

[HTML][HTML] Molecular changes tracking through multiscale fluorescence microscopy differentiate Meningioma grades and non-tumoral brain tissues

H Mehidine, M Refregiers, F Jamme, P Varlet… - Scientific reports, 2021 - nature.com
Meningioma is the most common primary intracranial extra-axial tumor. Total surgical
removal is the standard therapeutic method to treat this type of brain tumors. However, the …

Integrated time-resolved fluorescence and diffuse reflectance spectroscopy instrument for intraoperative detection of brain tumor margin

Z Nie, VN Du Le, D Cappon, J Provias… - IEEE Journal of …, 2015 - ieeexplore.ieee.org
Time-resolved fluorescence (TRF) and diffuse reflectance (DR) spectroscopy are two optical
biopsy modalities that have been studied in tumor diagnosis. Combination of TRF and DR …