Fluorescence-guided surgery is a state-of-the-art approach for intraoperative imaging during
neurosurgical removal of tumor tissue. While the visualization of high-grade gliomas is …

Fluorescence spectroscopy of the endogenous emission of brain tumors has been
researched as a potentially important method for the intraoperative localization of brain …

Biomarkers are indicators of biological processes and hold promise for the diagnosis and
treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked …

Abstract Development of cancer is accompanied by biochemical and structural changes in
the tissue and can be monitored by various optical techniques. Human tissue contains …

Purpose Modern techniques for improved tumor visualization have the aim to maximize the
extent of resection during brain tumor surgery and thus improve patient prognosis. Optical …

Native fluorescence spectrum of normal and cancerous human prostate tissues is studied to
distinguish between normal and cancerous tissues, and cancerous tissues at different …

Background Noninvasive intraoperative optical biopsy that provides real-time imaging of
histoarchitectural (cell resolution) features of brain tumors, especially at the margin of …

Studies have shown that fluorescent agents demarcate tumor from surrounding brain tissue
and offer intraoperative guidance during resection. However, visualization of fluorescence …

Intraoperative cancer imaging and fluorescence-guided surgery have attracted considerable
interest because fluorescence signals can provide real-time guidance to assist a surgeon in …

The intrinsic autofluorescence properties of biological tissues can be affected by the
occurrence of histological and biochemical alterations induced by pathological processes. In …