Progranulin: normal function and role in neurodegeneration
JL Eriksen, IRA Mackenzie - Journal of neurochemistry, 2008 - Wiley Online Library
Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …
neuroscience community following the recent discovery of PGRN mutations in some cases …
[HTML][HTML] Progranulin in frontotemporal lobar degeneration and neuroinflammation
Z Ahmed, IRA Mackenzie, ML Hutton… - Journal of …, 2007 - Springer
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …
community with recent discoveries of mutations in the gene for PGRN that cause …
[HTML][HTML] Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
P Van Damme, A Van Hoecke… - The Journal of cell …, 2008 - ncbi.nlm.nih.gov
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …
Structure, function, and mechanism of progranulin; the brain and beyond
H Toh, BP Chitramuthu, HPJ Bennett… - Journal of Molecular …, 2011 - Springer
Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …
a form of frontotemporal lobar degeneration that is characterized by the presence of …
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease
BP Chitramuthu, HPJ Bennett, A Bateman - Brain, 2017 - academic.oup.com
Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells
Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is
implicated in neuronal survival on the basis that mutations in the GRN gene causing …
implicated in neuronal survival on the basis that mutations in the GRN gene causing …
[HTML][HTML] Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions.
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …
[HTML][HTML] Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
P Bossù, F Salani, A Alberici, S Archetti… - Journal of …, 2011 - Springer
The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory
actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been …
actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
Progranulin: functions and neurologic correlations
RA Townley, BF Boeve, EE Benarroch - Neurology, 2018 - AAN Enterprises
Progranulin is a highly conserved secreted protein that is expressed in multiple cell types,
both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins …
both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins …