Heterochromatin in the fungal plant pathogen, Zymoseptoria tritici: Control of transposable elements, genome plasticity and virulence

CJ Fraser, SK Whitehall - Frontiers in Genetics, 2022 - frontiersin.org
Heterochromatin is a repressive chromatin state that plays key roles in the functional
organisation of eukaryotic genomes. In fungal plant pathogens, effector genes that are …

Chromatin dynamics contribute to the spatiotemporal expression pattern of virulence genes in a fungal plant pathogen

L Meile, J Peter, G Puccetti, J Alassimone… - MBio, 2020 - Am Soc Microbiol
Dynamic changes in transcription profiles are key for the success of pathogens in colonizing
their hosts. In many pathogens, genes associated with virulence, such as effector genes, are …

The chromodomain proteins, Cbx1 and Cbx2 have distinct roles in the regulation of heterochromatin and virulence in the fungal wheat pathogen, Zymoseptoria tritici

CJ Fraser, JC Rutherford, JJ Rudd, SK Whitehall - BioRxiv, 2022 - biorxiv.org
Heterochromatin is characterized by specific histone post-translational modifications such as
the di-and tri-methylation of histone H3 on lysine 9 (H3K9me2/3), which direct the …

In planta chromatin immunoprecipitation in Zymoseptoria tritici reveals chromatin-based regulation of putative effector gene expression

JL Soyer, J Grandaubert, J Haueisen, K Schotanus… - BioRxiv, 2019 - biorxiv.org
During infection, pathogens secrete effectors, key elements of pathogenesis. In several
phytopathogenic fungi, synchronous waves of effector genes are expressed during plant …

Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq)

JL Soyer, M Möller, K Schotanus, LR Connolly… - Fungal Genetics and …, 2015 - Elsevier
The presence or absence of specific transcription factors, chromatin remodeling
machineries, chromatin modification enzymes, post-translational histone modifications and …

Sas3-mediated histone acetylation regulates effector gene activation in a fungal plant pathogen

M Suarez-Fernandez, R Álvarez-Aragón… - Mbio, 2023 - Am Soc Microbiol
Effector proteins are secreted by plant pathogens to enable host colonization. Typically,
effector genes are tightly regulated, have very low expression levels in axenic conditions …

H4K20me3 is important for Ash1-mediated H3K36me3 and transcriptional silencing in facultative heterochromatin in a fungal pathogen

M Möller, JB Ridenour, DF Wright, FA Martin… - PLoS …, 2023 - journals.plos.org
Facultative heterochromatin controls development and differentiation in many eukaryotes. In
metazoans, plants, and many filamentous fungi, facultative heterochromatin is characterized …

Repeat-Induced Point Mutation and Gene Conversion Coinciding with Heterochromatin Shape the Genome of a Plant-Pathogenic Fungus

J Komluski, M Habig, EH Stukenbrock - Mbio, 2023 - Am Soc Microbiol
Meiosis is associated with genetic changes in the genome—via recombination, gene
conversion, and mutations. The occurrence of gene conversion and mutations during …

Functional analysis of a W heat H omeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in …

J Lee, B Orosa, L Millyard, M Edwards… - New …, 2015 - Wiley Online Library
A distinguishing feature of Septoria leaf blotch disease in wheat is the long symptomless
growth of the fungus amongst host cells followed by a rapid transition to necrotrophic growth …

Modify the histone to win the battle: chromatin dynamics in plant–pathogen interactions

JS Ramirez-Prado, SJM Piquerez… - Frontiers in Plant …, 2018 - frontiersin.org
Relying on an immune system comes with a high energetic cost for plants. Defense
responses in these organisms are therefore highly regulated and fine-tuned, permitting them …