Cognitive and behavioral comorbidities: an unwanted effect of antiepileptic drugs in children

A Ulate-Campos, IS Fernández - Seminars in Pediatric Neurology, 2017 - Elsevier
Epilepsy is one of the most common neurological disorders and, despite optimally chosen
and dosed antiepileptic drugs (AEDs), approximately 20%-30% of patients will continue to …

A long-term open-label extension study assessing cognition and behavior, tolerability, safety, and efficacy of adjunctive levetiracetam in children aged 4 to 16 years …

J Schiemann-Delgado, H Yang, C Loge… - Journal of child …, 2012 - journals.sagepub.com
The objective of this study was to assess cognition and behavior in children (4-16 years; n=
103) with partial-onset seizures using the Leiter-R International Performance Scale and …

Cognitive profile, psychopathological symptoms, and quality of life in newly diagnosed pediatric epilepsy: A six-month, naturalistic follow-up study

Ž Rogač, D Stevanović, S Bečanović, L Božić… - Epilepsy Research, 2022 - Elsevier
Long-term studies indicated changes in aspects of cognition, psychopathology, and quality
of life (QOL) in children and adolescents followed up after the diagnosis of epilepsy …

Executive function and health-related quality of life in pediatric epilepsy

WA Schraegle, JB Titus - Epilepsy & Behavior, 2016 - Elsevier
Children and adolescents with epilepsy often show higher rates of executive functioning
deficits and are at an increased risk of diminished health-related quality of life (HRQOL). The …

Baseline cognition, behavior, and motor skills in children with new‐onset, idiopathic epilepsy

VV Bhise, GD Burack… - … Medicine & Child …, 2010 - Wiley Online Library
Aim Epilepsy is associated with difficulties in cognition and behavior in children. These
problems have been attributed to genetics, ongoing seizures, psychosocial issues …

Patients with epilepsy: cognitively compromised before the start of antiepileptic drug treatment?

J Taylor, R Kolamunnage‐Dona, AG Marson… - …, 2010 - Wiley Online Library
Purpose: To compare the cognitive profile of newly diagnosed untreated epilepsy patients
with healthy volunteers using a comprehensive neuropsychological test battery. Methods: A …

Frontal lobe dysfunction in children with temporal lobe epilepsy

P Rzezak, D Fuentes, CA Guimarães… - Pediatric …, 2007 - Elsevier
There is evidence that adults with temporal lobe epilepsy present executive impairments.
However, there is limited information in children, especially when using a comprehensive …

Neurocognitive effects of phenobarbital discontinuation in epileptic children

SH Tonekaboni, N Beyraghi, HS Tahbaz… - Epilepsy & Behavior, 2006 - Elsevier
PURPOSE: Phenobarbital (PB) is the most widely used antiepileptic drug in the world, but its
possible deleterious cognitive and behavioral side effects remain an important concern …

[HTML][HTML] The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures

F Donati, G Gobbi, J Campistol, G Rapatz, M Daehler… - Seizure, 2007 - Elsevier
OBJECTIVE: To investigate the effect of oxcarbazepine against standard antiepileptic drug
therapy (carbamazepine and valproate) on cognitive function in children and adolescents …

Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study

YJ Chen, WM Kang, WCM So - Epilepsia, 1996 - Wiley Online Library
Using a randomized parallel group study design, we compared the cognitive effects of
carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) in children with epilepsy …