The activation of oxygenated hemoglobin (oxy-Hb) has been shown to be lacking in the
prefrontal cortex (PFC) of patients with late-onset depression (LOD), in verbal fluency task …

Aim: Functional neuroimaging studies to date have indicated prefrontal dysfunction in late‐
onset major depression (LOD). The relationships between prefrontal dysfunction and clinical …

Multi-channel near-infrared spectroscopy (NIRS) is a noninvasive, on-the-spot, functional
neuroimaging technique allowing detection of the spatiotemporal characteristics of brain …

Objective Subthreshold depression is an essential precursor and risk factor for major
depressive disorder, and its accurate identification and timely intervention are important for …

Background: Individuals with late‐life depression can be divided into two categories, those
with early and late‐onset depression (EOD and LOD, respectively). It has been reported that …

Reduced haemodynamic response in the frontotemporal cortices of patients with major
depressive disorder (MDD) has been demonstrated using functional near-infrared …

Background Gender plays a role in the mechanisms of depression, but fewer studies have
focused on gender differences in the abnormal activation of brain regions when patients …

A number of studies have demonstrated impairment of working memory (WM) in patients
with major depressive disorder (MDD). However, the relationship between the underlying …

Objective The study investigated cognitive performance and brain function between
treatment-resistant depression (TRD) and non-TRD patients to find potential neurobiological …

Aim: To evaluate the severity of depression by measuring alterations in prefrontal cortical
activity associated with mood disorders, as assessed on near‐infrared spectroscopy …