The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is
increasing, and very few novel molecules have been discovered since the 1960s. In this …

A major public health challenge today is the resurgence of microbial infections caused by
multidrug-resistant strains. Consequently, novel antimicrobial molecules are actively sought …

The emergence of superbugs developing resistance to antibiotics and the resurgence of
microbial infections have led scientists to start an antimicrobial arms race. In this context, we …

In a scenario where the discovery of new molecules to fight antibiotic resistance is a public
health concern, ribosomally synthesized and post-translationally modified peptides …

The human microbiota plays a central role in human physiology. This complex ecosystem is
a promising but untapped source of bioactive compounds and antibiotics that are critical for …

Ruminococcin A (RumA) is a lanthipeptide with high activity against pathogenic clostridia
and is naturally produced by the strict anaerobic bacterium Ruminococcus gnavus E1 …

Despite its major importance in human health, the metabolic potential of the human gut
microbiota is still poorly understood. We have recently shown that biosynthesis of …

Antimicrobial peptides (AMPs) are a promising class of compounds being developed
against multi-drug resistant bacteria. Hybridization has been reported to increase …

Antimicrobial peptides consist mainly of membrane-active sequences, which are potentially
relevant to antibiotic resistance era. In this context, a novel family of peptides isolated from …

The abuse of antibiotics leads to the increase of bacterial resistance, which seriously
threatens human health. Therefore, there is an urgent need to find effective alternatives to …