A robust signaling network is essential for cell survival. At the molecular level, this is often
mediated by as many as 200 different types of post‐translational modifications (PTMs) that …

Lysine acetylation has emerged as one of the most important post-translational
modifications, regulating different biological processes. However, its regulation by lysine …

Like protein phosphorylation, the posttranslational addition of acetyl groups to lysine
residues of eukaryotic and prokaryotic proteins has been known for decades. The discovery …

Protein acetylation is a key post-translational modification that regulates diverse biological
activities in eukaryotes. Here we report bioorthogonal chemical reporters that enable direct …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Lysine acetylation is a well-studied post-translational modification on both histone and
nonhistone proteins. More than 2000 acetylated proteins and 4000 lysine acetylation sites …

Acetylation, through the post-transcriptional modification of histones, is a well-established
regulator of gene transcription. More recent research has also identified an important role for …

Histone lysine acetyltransferases (KATs) catalyze the transfer of the acetyl group from acetyl
Coenzyme A to lysine residues in histones and nonhistone proteins. Here, we report …

Histone acetylation, methylation, and phosphorylation occur predominantly in the
unstructured N‐terminal domains or histone “tails”. These modifications and others comprise …

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