BACKGROUND & AIMS: The hepatocyte growth factor (HGF)/mesenchymal-epithelial
transition factor (c-Met) system is an essential inducer of hepatocyte growth and …

Hepatocyte growth factor (HGF)/c‐Met supports a pleiotrophic signal transduction pathway
that controls stem cell homeostasis. Here, we directly addressed the role of c‐Met in stem …

Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance
during development as well as in tumorigenesis. Because homozygous null mice for either …

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on
various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue …

HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during
liver regeneration. HGF treatment accelerates resolution of fibrosis in experimental animal …

Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it
stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various …

Background Acute liver failure (ALF) is characterized by impaired regeneration of
hepatocytes, partially resulting from the defective signaling between elevated levels of …

Background Previous work has established that HGF/c-Met signaling plays a pivotal role in
regulating the onset of S phase following partial hepatectomy (PH). In this study, we used …

Background At present hepatocyte transplantation is a promising option for cellular therapy
of end-stage liver diseases. However, the underlying molecular mechanisms need to be …

The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction
pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met …