Liver cirrhosis is the fatal end stage of various chronic liver diseases. One of the most
important causes of liver cirrhosis appears to be an impaired proliferative capability of …

Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …

Epithelial‐to‐mesenchymal transition (EMT) is predicted to play a critical role in metastatic
disease in hepatocellular carcinoma. In this study, we used a novel murine model of EMT to …

Epithelial-mesenchymal transition (EMT) occurs during adult tissue remodeling responses
including carcinogenesis and fibrosis. Existing evidence reveals that hepatocytes can …

BACKGROUND/AIMS: It is unknown whether heparin-binding EGF-like growth factor (HB-
EGF) can be a therapeutic agent, although previous studies suggested that HB-EGF might …

Many cytokines are involved in the repair of damaged tissue, and one of these, hepatocyte
growth factor (HGF), is involved not only with liver regeneration but also in the repair of other …

BACKGROUND & AIMS: Repair responses define the ultimate outcomes of liver disease.
This study evaluated the hypothesis that fibrogenic repair in nonalcoholic fatty liver disease …

Hepatocyte growth factor (HGF) is a multipotent endogenous repair factor secreted primarily
by mesenchymal cells with effects on cells expressing its receptor, Met. HGF promotes …

Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation
during liver fibrosis. The origin of such fibroblasts is still debated, although several studies …

The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c‐Met, plays a role in
tumour promotion, progression and metastasis. In this study, we analysed chemically …