Clinical trials targeting secondary damage after traumatic spinal cord injury

ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Emerging therapeutic strategies for traumatic spinal cord injury

F Torregrossa, M Sallì, G Grasso - World Neurosurgery, 2020 - Elsevier
Spinal cord injury (SCI) is a debilitating neurologic condition with tremendous
socioeconomic impact on affected individuals and the health care system. The treatment of …

Recent progress and challenges in the treatment of spinal cord injury

T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

Combinatorial therapies for spinal cord injury repair

CS Sousa, A Monteiro, AJ Salgado… - Neural Regeneration …, 2025 - journals.lww.com
Spinal cord injuries have profound detrimental effects on individuals, regardless of whether
they are caused by trauma or non-traumatic events. The compromised regeneration of the …

Emerging drugs for spinal cord injury

DC Baptiste, MG Fehlings - Expert opinion on emerging drugs, 2008 - Taylor & Francis
Background: This review summarizes several promising pharmacological approaches for
the therapeutic management of traumatic spinal cord injury (SCI), which are either in early …

Advances in molecular therapies for targeting pathophysiology in spinal cord injury

HN Kim, MR McCrea, S Li - Expert opinion on therapeutic targets, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

[HTML][HTML] Established and emerging therapies in acute spinal cord injury

R Gadot, DN Smith, M Prablek, JK Grochmal… - Neurospine, 2022 - ncbi.nlm.nih.gov
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an
annual incidence of 20–50 per million people. Following initial assessment with appropriate …

Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury

AM Siddiqui, M Khazaei, MG Fehlings - Progress in brain research, 2015 - Elsevier
One of the big challenges in neuroscience that remains to be understood is why the central
nervous system is not able to regenerate to the extent that the peripheral nervous system …