Modern drug development problems are very complex and require integration of various
scientific fields. Traditionally, statistical methods have been the primary tool for design and …

Pharmacometrics is an interdisciplinary science with tremendous potential to influence
decision making through the construction of mathematical and statistical models combined …

As part of a series of articles celebrating the American Statistical Association's 175th
anniversary in 2014, this article provides a historical perspective of key statistical …

The inability to establish safety and/or efficacy of the drugs has always been the chief source
for clinical trial failures and it is disappointing that even if a drug successfully enters the …

I was very honored to receive the University of California, San Francisco, and the
International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the …

Pharmacometrics is the science of interpreting and describing pharmacology in a
quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its …

Abstract Pharmacometrics—pharmacokinetics/pharmacodynamics (PK/PD) modeling and
simulation—has been used to inform drug development decisions for more than two …

Pharmacometrics and systems pharmacology are emerging as principal quantitative
sciences within drug development and experimental therapeutics. In recognition of the …

Quantitative systems pharmacology (QSP) models are an important facet of pharmaceutical
and clinical research as they combine mechanistic models of physiology in health and …

The history of the development of pharmacometrics (PM) is traced from its roots in
pharmacokinetics and pharmacodynamics through population pharmacokinetics to …