Evidence from animal and human studies suggests that moderate acoustic exposure,
causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that …

Little is known about how outer hair cell loss interacts with noise-induced and age-related
auditory nerve degradation (ie, cochlear synaptopathy) to affect auditory brainstem response …

Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been
demonstrated in animal models using histological techniques. However, diagnosis of the …

Objectives: Recent animal studies demonstrated that cochlear synaptopathy, a partial loss of
inner hair cell-auditory nerve fiber synapses, can occur in response to noise exposure …

In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

For decades, we have presumed the death of hair cells and spiral ganglion neurons are the
main cause of hearing loss and difficulties understanding speech in noise, but new findings …

Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies.
In these animal models, the disorder is characterized by a reduction in amplitude of wave I of …

Although there is strong histological evidence for age-related synaptopathy in humans,
evidence for the existence of noise-induced cochlear synaptopathy in humans is …

Permanent threshold elevation after noise exposure or aging is caused by loss of sensory
cells; however, animal studies show that hair cell loss is often preceded by degeneration of …