The dysregulation of food intake in chronic obesity has been explained by different theories.
To assess their explanatory power, we meta-analyzed 22 brain-activation imaging studies …

There is a well-established literature linking obesity to altered dopamine signaling and brain
response to food-related stimuli. Neuroimaging studies frequently report enhanced …

Advances in neuroimaging techniques have provided insight into the role of the brain in the
regulation of food intake and weight. Growing evidence demonstrate that energy dense …

Obese individuals react to cues of high caloric food with enhanced craving and brain reward
system activation. In the present study, we analyzed neural correlates of craving regulation …

Obesity is a neurobehavioral disorder that results from a combination of overeating and
insufficient physical activity. Finely tuned mechanisms exist to match food intake to caloric …

The neural systems regulating food intake in obese individuals remain poorly understood.
Previous studies applied positron emission tomography and manipulated hunger and satiety …

Using neuroimaging technologies to compare normal weight and obese individuals can
reveal much about the pathophysiological state of obesity but such comparisons tell us little …

Appetite and body weight regulation are controlled by the central nervous system (CNS) in a
rather complicated manner. The human brain plays a central role in integrating internal and …

The mere sight of foods may activate the brain's reward circuitry, and humans often
experience difficulties in inhibiting urges to eat upon encountering visual food signals …

Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …