In adult neurogenesis, where new functional neurons are generated from precursor cells,
certain neurological conditions like seizures can disrupt the normal production, migration …

Epilepsy is a chronic neurological disorder characterized by hypersynchronous
spontaneous recurrent seizures, and affects approximately 50 million people worldwide …

Several factors, including epileptic seizures, can strongly stimulate ongoing neurogenesis in
the adult hippocampus. Although adult‐born granule cells generated after seizure activity …

The functional impact of adult-generated granule cells in the epileptic brain is unclear, with
data supporting both protective and maladaptive roles. These conflicting findings could be …

Hippocampal neurogenesis continues throughout life in mammals–including humans.
During the development of temporal lobe epilepsy, newly-generated hippocampal granule …

Temporal lobe epilepsy is associated with dramatic changes in hippocampal granule cell
neurogenesis, affecting cell proliferation, survival, and integration. In adult animals …

The migration of neurons from their birthplace to their correct destination is one of the most
crucial steps in brain development. Incomplete or incorrect migration yields ectopic neurons …

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function
of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent …

Adult generated neurons in the dentate gyrus become functionally integrated into the
existing hippocampal circuit by forming synapses with mature neurons. It is now well …

Neuronal migration to the exact destination is one of the critical steps in the development of
the brain. Incomplete or incorrect migration yields ectopic neurons, which can cause …