[HTML][HTML] Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …
an approach to stratify individuals based on genetic risk for disease. Using recent …
[HTML][HTML] Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score
Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …
importance. Although genetic studies have identified AD-associated SNPs in APOE and …
Genome-wide association studies for Alzheimer's disease: bigger is not always better
V Escott-Price, J Hardy - Brain Communications, 2022 - academic.oup.com
As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …
identified inevitably increase. One welcomes this if it allows the better delineation of the …
Polygenic risk and hazard scores for Alzheimer's disease prediction
Objective Genome‐wide association studies (GWAS) have identified over 30 susceptibility
loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International …
loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International …
Transferability of Alzheimer disease polygenic risk score across populations and its association with Alzheimer disease-related phenotypes
Importance Polygenic risk scores (PRSs), which aggregate the genetic effects of single-
nucleotide variants identified in genome-wide association studies (GWASs), can help …
nucleotide variants identified in genome-wide association studies (GWASs), can help …
[HTML][HTML] Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Background Alzheimer's disease is a common debilitating dementia with known heritability,
for which 20 late onset susceptibility loci have been identified, but more remain to be …
for which 20 late onset susceptibility loci have been identified, but more remain to be …
[HTML][HTML] Alzheimer's disease: analyzing the missing heritability
Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …
[HTML][HTML] Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration
MS Tan, YX Yang, W Xu, HF Wang, L Tan… - Alzheimer's Research & …, 2021 - Springer
Background Genome-wide association studies have identified more than 30 Alzheimer's
disease (AD) risk genes, although the detailed mechanism through which all these genes …
disease (AD) risk genes, although the detailed mechanism through which all these genes …
[HTML][HTML] Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci
A Witoelar, A Rongve, IS Almdahl, ID Ulstein… - Scientific reports, 2018 - nature.com
A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified,
limiting the understanding of AD pathology and study of therapeutic targets. We conducted a …
limiting the understanding of AD pathology and study of therapeutic targets. We conducted a …
Common polygenic variation enhances risk prediction for Alzheimer's disease
The identification of subjects at high risk for Alzheimer's disease is important for prognosis
and early intervention. We investigated the polygenic architecture of Alzheimer's disease …
and early intervention. We investigated the polygenic architecture of Alzheimer's disease …