Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis
Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
[HTML][HTML] Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer
Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
Targeting HGF/c-MET axis in pancreatic cancer
Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …
disease that is associated with early metastases. It is characterized by dense and …
Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …
microenvironment and are considered to contribute to chemoresistance. PSCs can …
Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
E Lonardo, J Frias-Aldeguer, PC Hermann… - Cell cycle, 2012 - Taylor & Francis
Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are characterized by
extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired …
extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired …
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α
B Yan, Z Jiang, L Cheng, KE Chen, C Zhou… - Experimental cell …, 2018 - Elsevier
Pancreatic stellate cells (PSCs), a pivotal component of the tumor microenvironment,
contribute to tumor growth and metastasis. PSC-derived factors are essential for triggering …
contribute to tumor growth and metastasis. PSC-derived factors are essential for triggering …
Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor/c-Met/survivin regulated by P53/P21
XP Yang, SL Liu, JF Xu, SG Cao, Y Li… - Experimental cell research, 2017 - Elsevier
Pancreatic stellate cells (PSCs) are a key cellular component of the pancreatic tumor
microenvironment and are considered to contribute to tumor invasion and metastasis …
microenvironment and are considered to contribute to tumor invasion and metastasis …
The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell–endothelial cell interactions: antiangiogenic implications in pancreatic cancer
MB Patel, SP Pothula, Z Xu, AK Lee… - …, 2014 - academic.oup.com
Activated cancer-associated human pancreatic stellate cells (CAhPSCs, which produce the
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …
Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment
AA Rucki, Q Xiao, S Muth, J Chen, X Che… - Molecular cancer …, 2017 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemotherapy-and
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …