Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

Y Uno, Y Igawa, M Tanaka, K Ohura, M Hosokawa… - Xenobiotica, 2019 - Taylor & Francis
Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and
xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus …
被引用次数：6 相关文章 所有 5 个版本

Systematic identification and characterization of carboxylesterases in cynomolgus macaques

Y Uno, S Uehara, M Hosokawa, T Imai - Drug Metabolism and Disposition, 2014 - ASPET
Carboxylesterase (CES) is important for detoxification of a wide range of drugs and
xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are …
被引用次数：12 相关文章 所有 5 个版本

Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2

J Wang, ET Williams, J Bourgea, YN Wong… - Drug Metabolism and …, 2011 - ASPET
Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …
被引用次数：126 相关文章 所有 7 个版本
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Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys

K Ohura, Y Igawa, M Tanaka, K Matsumoto… - Drug Metabolism and …, 2020 - ASPET
In contrast to a single human carboxylesterase 2 (CES2) isozyme (hCE2), three CES2
genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C …
被引用次数：3 相关文章 所有 5 个版本
[HTML] nih.gov

Mammalian carboxylesterase 3: comparative genomics and proteomics

RS Holmes, LA Cox, JL VandeBerg - Genetica, 2010 - Springer
At least five families of mammalian carboxylesterases (CES) catalyse the hydrolysis or
transesterification of a wide range of drugs and xenobiotics and may also participate in fatty …
被引用次数：33 相关文章 所有 17 个版本

Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1

D Bjerre, HB Rasmussen… - Pharmacogenetics …, 2017 - journals.lww.com
Abstract Carboxylesterase 1 (CES1) is implicated in the metabolism of several commonly
used drugs and other xenobiotics. The gene encoding this enzyme, CES1, is duplicated in …
被引用次数：10 相关文章 所有 6 个版本
[HTML] nih.gov

Examination of the carboxylesterase phenotype in human liver

MK Ross, A Borazjani, R Wang, JA Crow… - Archives of biochemistry …, 2012 - Elsevier
Carboxylesterases (CES) metabolize esters. Two CES isoforms are expressed in human
liver (CES1 and CES2) and liver extracts are used in reaction phenotyping studies to discern …
被引用次数：66 相关文章 所有 9 个版本
[PDF] psu.edu

Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human

ET Williams, JA Bacon, DM Bender, JJ Lowinger… - Drug metabolism and …, 2011 - ASPET
The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2 …
被引用次数：70 相关文章 所有 8 个版本
[PDF] jst.go.jp

Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes

M Hosokawa, T Furihata, Y Yaginuma… - Drug metabolism and …, 2008 - Elsevier
Mammalian carboxylesterases comprise a multigene family, the gene products of which are
localized in the endoplasmic reticulum. The carboxylesterases catalyze the hydrolysis of …
被引用次数：62 相关文章 所有 8 个版本

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes

T Fukami, M Nakajima, T Maruichi… - Pharmacogenetics …, 2008 - journals.lww.com
Objective Human carboxylesterase (CES) 1A1 gene (14 exons) and CES1A3 pseudogene
(six exons) are inverted and duplicated genes in a reference sequence (NT_010498). In …
被引用次数：86 相关文章 所有 8 个版本