Orexin-mediated feeding behavior involves both leptin-sensitive and-insensitive pathways

Y Zhu, A Yamanaka, K Kunii, N Tsujino, K Goto… - Physiology & …, 2002 - Elsevier
Orexin-A and-B are neuropeptides that are implicated in the regulation of vigilance states
and energy homeostasis. Orexins are specifically produced by neurons located within the …

Feeding and activity induced by orexin A in the lateral hypothalamus in rats

CM Kotz, JA Teske, JA Levine, CF Wang - Regulatory peptides, 2002 - Elsevier
Orexin A injected into the lateral hypothalamus (LH) stimulates feeding and activates
neurons in brain sites regulating feeding and arousal. The feeding effects of orexin A have …

Orexin A-induced feeding is augmented by caloric challenge

AJ Thorpe, JA Teske, CM Kotz - American Journal of …, 2005 - journals.physiology.org
Orexin neurons are stimulated by conditions that are glucoprivic, suggesting that orexin
signaling may be increased during nutritional duress. We have previously shown that …

Roles of orexins in the regulation of body weight homeostasis

T Sakurai - Obesity research & clinical practice, 2014 - Elsevier
Lateral hypothalamic neuropeptides, orexins, have been recognized as one of the most
important regulators of sleep/wakefulness states. Besides, these peptides are also regarded …

Evidence for the role of hindbrain orexin-1 receptors in the control of meal size

EM Parise, N Lilly, K Kay, AM Dossat… - American Journal …, 2011 - journals.physiology.org
Hypothalamic orexin neurons project to the hindbrain, and 4th-ventricle
intracerebroventricular (4th-icv) injection of orexin-A treatment increases food intake. We …

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin …

S Muroya, H Funahashi, A Yamanaka… - European Journal of …, 2004 - Wiley Online Library
Orexin‐A and‐B (hypocretin‐1 and‐2) have been implicated in the stimulation of feeding.
Here we show the effector neurons and signaling mechanisms for the orexigenic action of …

Orexin-induced food intake involves neuropeptide Y pathway

A Yamanaka, K Kunii, T Nambu, N Tsujino, A Sakai… - Brain research, 2000 - Elsevier
Orexins (orexin-A and-B) are recently identified neuropeptides, which are thought to be
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific …

[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

T Sakurai, A Amemiya, M Ishii, I Matsuzaki… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same …

Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis

T Sakurai - CNS & Neurological Disorders-Drug Targets …, 2006 - ingentaconnect.com
Orexins were initially recognized as regulators of feeding behavior due to their exclusively
production in the lateral hypothalamic area (LHA), a feeding center. Subsequently, the …

Food restriction selectively increases hypothalamic orexin-B levels in lactating rats

XJ Cai, R Denis, RG Vernon, JC Clapham, S Wilson… - Regulatory peptides, 2001 - Elsevier
Orexins are hypothalamic peptides implicated in the regulation of ingestive and other
behaviours. Here we investigated prepro-orexin expression and hypothalamic orexin-A and …