Orexin-mediated feeding behavior involves both leptin-sensitive and-insensitive pathways
Y Zhu, A Yamanaka, K Kunii, N Tsujino, K Goto… - Physiology & …, 2002 - Elsevier
Orexin-A and-B are neuropeptides that are implicated in the regulation of vigilance states
and energy homeostasis. Orexins are specifically produced by neurons located within the …
and energy homeostasis. Orexins are specifically produced by neurons located within the …
Feeding and activity induced by orexin A in the lateral hypothalamus in rats
Orexin A injected into the lateral hypothalamus (LH) stimulates feeding and activates
neurons in brain sites regulating feeding and arousal. The feeding effects of orexin A have …
neurons in brain sites regulating feeding and arousal. The feeding effects of orexin A have …
Orexin A-induced feeding is augmented by caloric challenge
Orexin neurons are stimulated by conditions that are glucoprivic, suggesting that orexin
signaling may be increased during nutritional duress. We have previously shown that …
signaling may be increased during nutritional duress. We have previously shown that …
Roles of orexins in the regulation of body weight homeostasis
T Sakurai - Obesity research & clinical practice, 2014 - Elsevier
Lateral hypothalamic neuropeptides, orexins, have been recognized as one of the most
important regulators of sleep/wakefulness states. Besides, these peptides are also regarded …
important regulators of sleep/wakefulness states. Besides, these peptides are also regarded …
Evidence for the role of hindbrain orexin-1 receptors in the control of meal size
Hypothalamic orexin neurons project to the hindbrain, and 4th-ventricle
intracerebroventricular (4th-icv) injection of orexin-A treatment increases food intake. We …
intracerebroventricular (4th-icv) injection of orexin-A treatment increases food intake. We …
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin …
S Muroya, H Funahashi, A Yamanaka… - European Journal of …, 2004 - Wiley Online Library
Orexin‐A and‐B (hypocretin‐1 and‐2) have been implicated in the stimulation of feeding.
Here we show the effector neurons and signaling mechanisms for the orexigenic action of …
Here we show the effector neurons and signaling mechanisms for the orexigenic action of …
Orexin-induced food intake involves neuropeptide Y pathway
A Yamanaka, K Kunii, T Nambu, N Tsujino, A Sakai… - Brain research, 2000 - Elsevier
Orexins (orexin-A and-B) are recently identified neuropeptides, which are thought to be
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific …
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific …
[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
T Sakurai, A Amemiya, M Ishii, I Matsuzaki… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same …
homeostasis. We have identified two novel neuropeptides, both derived from the same …
Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis
T Sakurai - CNS & Neurological Disorders-Drug Targets …, 2006 - ingentaconnect.com
Orexins were initially recognized as regulators of feeding behavior due to their exclusively
production in the lateral hypothalamic area (LHA), a feeding center. Subsequently, the …
production in the lateral hypothalamic area (LHA), a feeding center. Subsequently, the …
Food restriction selectively increases hypothalamic orexin-B levels in lactating rats
XJ Cai, R Denis, RG Vernon, JC Clapham, S Wilson… - Regulatory peptides, 2001 - Elsevier
Orexins are hypothalamic peptides implicated in the regulation of ingestive and other
behaviours. Here we investigated prepro-orexin expression and hypothalamic orexin-A and …
behaviours. Here we investigated prepro-orexin expression and hypothalamic orexin-A and …