Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity

AR Last, H Pickering, C Roberts, F Coll, J Phelan… - Genome medicine, 2018 - Springer
Abstract Background Chlamydia trachomatis (Ct) is the most common infectious cause of
blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific …

Genomic insights into local-scale evolution of ocular Chlamydia trachomatis strains within and between individuals in Gambian trachoma-endemic villages

E Ghasemian, N Faal, H Pickering… - Microbial …, 2024 - microbiologyresearch.org
Trachoma, a neglected tropical disease caused by Chlamydia trachomatis (Ct) serovars A–
C, is the leading infectious cause of blindness worldwide. Africa bears the highest burden …

Whole-genome sequencing of ocular Chlamydia trachomatis isolates from Gadarif State, Sudan

AAI Alkhidir, MJ Holland, WI Elhag, CA Williams… - Parasites & vectors, 2019 - Springer
Background Trachoma, caused by ocular Chlamydia trachomatis, is the leading infectious
cause of blindness worldwide. Sudan first reported trachoma in the 1930s and has since …

Pathogenic Diversity among Chlamydia trachomatis Ocular Strains in Nonhuman Primates Is Affected by Subtle Genomic Variations

L Kari, WM Whitmire, JH Carlson… - The Journal of …, 2008 - academic.oup.com
Chlamydia trachomatis is the etiological agent of trachoma, the leading cause of
preventable blindness. Trachoma presents distinct clinical syndromes ranging from mild and …

Genome-wide identification of Chlamydia trachomatis antigens associated with trachomatous trichiasis

C Lu, MJ Holland, S Gong, B Peng… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Chlamydia trachomatis is the leading infectious cause of blindness. The goal of
the current study was to search for biomarkers associated with C. trachomatis–induced …

Genomics of Ocular Chlamydia trachomatis After 5 Years of SAFE Interventions for Trachoma in Amhara, Ethiopia

H Pickering, A Chernet, E Sata… - The Journal of …, 2022 - academic.oup.com
Background To eliminate trachoma as a public health problem, the World Health
Organization recommends the SAFE (surgery, antibiotics, facial cleanliness, and …

Chlamydia trachomatis ompA Variants in Trachoma: What Do They Tell Us?

AA Andreasen, MJ Burton, MJ Holland… - PLoS neglected …, 2008 - journals.plos.org
Background Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious
cause of blindness. Sequence-based analysis of the multiple strains typically present in …

Unravelling Chlamydia trachomatis diversity in Amhara, Ethiopia: MLVA-ompA sequencing as a molecular typing tool for trachoma

AJ Harte, E Ghasemian, H Pickering… - PLOS Neglected …, 2024 - journals.plos.org
Trachoma is the leading infectious cause of blindness worldwide and is now largely
confined to around 40 low-and middle-income countries. It is caused by Chlamydia …

Comparison of genovars and Chlamydia trachomatis infection loads in ocular samples from children in two distinct cohorts in Sudan and Morocco

E Ghasemian, A Inic-Kanada, A Collingro… - PLoS Neglected …, 2021 - journals.plos.org
Trachoma is a blinding disease caused by repeated conjunctival infection with different
Chlamydia trachomatis (Ct) genovars. Ct B genovars have been associated with more …

Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study

CH Roberts, CS Franklin, P Makalo, H Joof, I Sarr… - Scientific reports, 2015 - nature.com
Chlamydia trachomatis causes both trachoma and sexually transmitted infections. These
diseases have similar pathology and potentially similar genetic predisposing factors. We …