Cx3cr1, the receptor for the chemokine Cx3cl1 (fractalkine), has been implicated in the
progression and severity of Alzheimer's disease-like pathology in mice, but the underlying …

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1)
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …

Microglia, the primary immune effector cells in the brain, continually monitor the tissue
parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss …

Background The primary neuropathological characteristics of AD include intracellular,
filamentous inclusions of hyperphosphorylated microtubule associated protein tau (MAPT) in …

The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine
receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly …

Aberrant microglial activation has been proposed to contribute to the cognitive decline in
Alzheimer disease (AD), but the underlying molecular mechanisms remain enigmatic …

Microglia and astrocytes are the major source of cytokines in Alzheimer, s disease (AD).
CX3CR1 is a delta chemokine receptor found in microglia and its neuronal ligand …

Microglia, the resident inflammatory cells of the CNS, are the only CNS cells that express the
fractalkine receptor (CX3CR1). Using three different in vivo models, we show that CX3CR1 …

Neuronal fractalkine acts via its receptor, CX3CR1, on microglia to regulate
neuroinflammation. Conflicting results have been reported in studies employing CX3CR1 …

Background Despite its identification as a key checkpoint regulator of microglial activation in
Alzheimer's disease, the overarching role of CX3CR1 signaling in modulating mechanisms …