Heart failure (HF) is one of the most prevalent cardiovascular diseases and is associated
with significant morbidity and a poor prognosis. Since the 1980s, HF phenotyping was …

Translating research into clinical practice has been a challenge throughout medical history.
From the present review, it should be clear that this is particularly the case for heart failure …

The prevalence and incidence of congestive heart failure (CHF) have assumed dramatic
dimensions at the close of the 20th century. 1 The life span for both men and women has …

Heart failure (HF) is a vicious circle in which an original insult leading to mechanical cardiac
dysfunction initiates multiple morphological, biochemical and molecular pathological …

In the past decades, myocardial infarction periacute mortality markedly declined since
coronary reperfusion therapy has been adopted. Despite immediate benefits of coronary …

Ventricular remodeling is a complex process that results from interactions between the initial
myocardial injury and neurohormonal factors that are capable of modifying the …

Heart failure is a progressive clinical syndrome that is characterized by remodeling of the
myocardium in response to various stress signals. The past several years has seen …

The failing heart is characterized by complex tissue remodelling involving increased
cardiomyocyte death, and impairment of sarcomere function, metabolic activity, endothelial …

The management of patients with heart failure (HF) is challenging and requires the
integration of clinical skills and accurate ancillary tests for the correct diagnosis and …

The history of the pharmacologic management of heart failure is, to a surprisingly large
extent, a story of theoretical promise and clinical disappointment. The traditional mechanistic …