Two conformationally constrained templates have been designed to provide selective
inhibitors of the coagulation cascade serine protease, Factor Xa (FXa). The most active …

To enhance the potency of 1, 2-dibenzamidobenzene-derived inhibitors of factor Xa (fXa),
an amidine substituent was incorporated on one of the benzoyl side chains to interact with …

We describe here our investigation of a new series of orally active fXa inhibitors based on a
prodrug strategy. Solid-phase parallel synthesis identified a unique series of fXa inhibitors …

Factor Xa (FXa) is a serine protease which plays a pivotal role in the coagulation cascade.
The inhibition of FXa has received great interest as a potential target for the development of …

Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-
ylsulfonyl) aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an …

The design, synthesis, and structure− activity relationship of 3-oxybenzamides as potent
inhibitors of the coagulation protease factor Xa are described on the basis of X-ray …

Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation
linking the intrinsic and extrinsic pathways to the final common pathway of the coagulation …

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing
effective and safe anticoagulants. Although a large number of FXa inhibitors have been …

As part of an ongoing effort to prepare orally active factor Xa inhibitors using structure-based
drug design techniques and molecular recognition principles, a systematic study has been …

An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally
modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid …