Androgens are essential for the development, growth, and maintenance of the prostate.
They exert their effects via the intracellular androgen receptor (AR), which is a ligand …

Despite earlier detection and recent advances in surgery and radiation, prostate cancer is
second only to lung cancer in male cancer deaths in the United States. Hormone therapy in …

Androgens are important not only for the development and function of the normal prostate
gland, but also for the maintenance of prostate cancer (PCa) cells. The biological function of …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Androgen deprivation has been the standard therapy for advanced and metastatic prostate
cancer for over half a century, as prostate tumors are initially dependent on androgens for …

Prostate cancer is the second most prevalent cancer in males in the United States. Standard
therapy relies on removing, or blocking the actions of, androgens. In most cases, this therapy …

Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is
expressed in all histological types and stages of prostate cancer. The AR regulates …

The last decade has brought increased awareness to prostate cancer as a significant health
problem. Prostate cancer is very heterogeneous in its etiology and progression, but …

During the course of prostate cancer progression, cells convert from an androgen‐
dependent to an androgen‐independent growth status. At this late stage, the role of the …

The importance of androgens and androgen receptors (AR) in primary prostate cancer is
well established. Metastatic disease is usually treated with some form of androgen ablation …