Antidiabetic Potential of the Heme Oxygenase‐1 Inducer Curcumin Analogues

Y Son, JH Lee, YK Cheong, HT Chung… - BioMed Research …, 2013 - Wiley Online Library
Although there is a therapeutic treatment to combat diabetes, the identification of agents that
may deal with its more serious aspects is an important medical field for research. Diabetes …

Therapeutic roles of heme oxygenase‐1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase‐1

Y Son, JH Lee, HT Chung… - Oxidative medicine and …, 2013 - Wiley Online Library
Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated
with a low‐grade chronic inflammation (inflammatory stress), oxidative stress, and …

[HTML][HTML] Effect of novel water soluble curcumin derivative on experimental type-1 diabetes mellitus (short term study)

MT Abdel Aziz, MF El-Asmar, IN El-Ibrashy… - Diabetology & metabolic …, 2012 - Springer
Background Diabetes mellitus type 1 is an autoimmune disorder caused by lymphocytic
infiltration and beta cells destruction. Curcumin has been identified as a potent inducer of …

Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse β-cells

S Pugazhenthi, L Akhov, G Selvaraj… - American Journal of …, 2007 - journals.physiology.org
Curcumin (diferuloylmethane), a component of turmeric, has been shown to have
therapeutic properties. Induction of phase 2 detoxifying enzymes is a potential mechanism …

Antidiabetic activity of curcumin: Insight Into its mechanisms of action

M Wojcik, M Krawczyk, LA Wozniak - Nutritional and therapeutic …, 2018 - Elsevier
Oxidative stress, defined as the imbalance between formation of reactive oxygen and
nitrogen species (ROS/RNS) and their elimination, has been implicated in the development …

Curcumin targeting oxidative mediators for therapeutic effects in diabetes and its related complications

Y Hussain, H Khan, W Alam, Z Ali, M Ibrar - Phytonutrients, 2022 - phytonutrients.pk
DIABETES mellitus is a multifactorial chronic metabolic disorder characterized by altered
metabolism of macro–nutrients such fats, proteins and carbohydrates associated with …

[HTML][HTML] How curcumin targets inflammatory mediators in diabetes: therapeutic insights and possible solutions

Y Hussain, H Khan, G Alotaibi, F Khan, W Alam… - Molecules, 2022 - mdpi.com
Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered
metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic …

Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications

B Meng, J Li, H Cao - Current pharmaceutical design, 2013 - ingentaconnect.com
Diabetes mellitus (DM) has reached pandemic status and shows no signs of abatement. It
can severely impair people's quality of life and affects patients all over the world. Since it is a …

[HTML][HTML] The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications

S Ghareghomi, M Rahban, Z Moosavi-Movahedi… - Molecules, 2021 - mdpi.com
Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …

Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and …

GS Jeong, GS Oh, HO Pae, SO Jeong… - … & molecular medicine, 2006 - nature.com
Recently, it has been reported that curcumin, which is known as a potent antioxidant, acts as
a non-stressful and non-cytotoxic inducer of the cytoprotective heme oxygenase (HO)-1. In …