Selenium-based drug design: rationale and therapeutic potential

SW May - Expert Opinion on Investigational Drugs, 1999 - Taylor & Francis
The wide media coverage given recently to a study correlating higher selenium levels with a
reduced risk of advanced prostate cancer is but the latest addition to a growing body of …

Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation

R Lobb - 2011 - researchcommons.waikato.ac.nz
Selenium (Se) is an essential trace mineral required in maintaining health in humans.
Recent research has demonstrated that Se shows promise as an agent that can reduce the …

Selenium-Containing Agents Acting on Cancer—A New Hope?

S Garbo, S Di Giacomo, D Łażewska… - Pharmaceutics, 2022 - mdpi.com
Selenium-containing agents are more and more considered as an innovative potential
treatment option for cancer. Light is shed not only on the considerable advancements made …

[引用][C] A review on Selenium compounds role in chemotherapy

P Keerthi, GR Challa Anitha, PS Babu - World J Pharm Res, 2017

In Vitro and in Vivo Studies of Methylseleninic Acid: Evidence That a Monomethylated Selenium Metabolite Is Critical for Cancer Chemoprevention

C Ip, HJ Thompson, Z Zhu, HE Ganther - Cancer research, 2000 - AACR
Previous research suggested that the β-lyase-mediated production of a monomethylated
selenium metabolite from Se-methylselenocysteine is a key step in cancer chemoprevention …

Differential effects of selenium (Se) on normal and malignant cells treated with chemotherapy (CT) and radiation (RT).

MB Jameson, RJ Lobb, GM Jacobson, RT Cursons - 2013 - ascopubs.org
e13583 Background: Preclinical work has demonstrated that Se compounds potentiate
anticancer effects of CT and RT while reducing normal tissue toxicities. The molecular basis …

Selenium as a cancer preventative and therapeutic agent: defining mechanisms of action and optimal doses

O Al Assaad - 2023 - openresearch.surrey.ac.uk
Abstract< b> Background</b> Selenium (Se) is an essential micronutrient that may exert
cancer-selective cytotoxicity at supranutritional exposures. It has been proposed Se exerts …

[引用][C] Selenium and Cancer Prevention

C IP, J MARSHALL, YMEE PARK, H ZHANG… - Nutritional …, 2006 - Elsevier

Apoptotic cellular events for selenium compounds involved in cancer prevention

H Rikiishi - Journal of bioenergetics and biomembranes, 2007 - Springer
Converging data from epidemiological, ecological, and clinical studies have shown that
selenium (Se) can decrease the risk for some types of human cancers. Induction of …

Reactive selenium species: Redox modulation, antioxidant, antimicrobial and anticancer activities

M Jawad Nasim, W Ali, E Domínguez-Álvarez… - 2017 - books.rsc.org
Since its discovery 200 years ago, in 1817, by Jöns Jacob Berzelius (1779–1848), the
element selenium has had a rather chequered relationship with biology and medicine, an …