Species-dependent variation in proteins that aid or limit virus replication determines the
ability of lentiviruses to jump between host species. Identifying and overcoming these …

Chimeric simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV)(SHIV)
infection of macaques is commonly used to model HIV type 1 (HIV-1) transmission and …

Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the
preferred model system for vaccine development because SHIVs encode human …

ABSTRACT HIV-1 replicates poorly in macaque cells, and this had hindered the
advancement of relevant nonhuman primate model systems for HIV-1 infection and …

Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env)
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …

Although Rhesus macaques are an important animal model for HIV-1 vaccine development
research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic …

To replicate in a new host, lentiviruses must adapt to exploit required host factors and evade
species-specific antiviral proteins. Understanding how host protein variation drives lentivirus …

Individuals chronically infected with HIV-1 harbor complex viral populations within their
bloodstreams. Recently, it has come to light that when these people infect others, the new …

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the
viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells …

ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …