V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
The SIV envelope glycoprotein, viral tropism, and pathogenesis: novel insights from nonhuman primate models of AIDS
AE Swanstrom, GQ Del Prete, C Deleage… - Current HIV …, 2018 - ingentaconnect.com
Background: Cellular tropism of human immunodeficiency virus (HIV-1) is closely linked to
interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine …
interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine …
Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following SIV challenges of vaccinated monkeys
Background A vaccine for HIV-1 would ideally block HIV-1 acquisition as well as durably
control viral replication in breakthrough infections. A recently published study showed that …
control viral replication in breakthrough infections. A recently published study showed that …
[HTML][HTML] Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes
M Asmal, C Luedemann, CL Lavine, LV Mach… - Virology, 2015 - Elsevier
Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder
(T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman …
(T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman …
New SHIVs and improved design strategy for modeling HIV-1 transmission, immunopathogenesis, prevention, and cure
H Li, S Wang, FH Lee, RS Roark, AI Murphy… - Journal of …, 2021 - Am Soc Microbiol
Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
[HTML][HTML] Breaking barriers to an AIDS model with macaque-tropic HIV-1 derivatives
R Thippeshappa, H Ruan, JT Kimata - Biology, 2012 - mdpi.com
The development of an animal model of human immunodeficiency virus type 1 (HIV-1)/AIDS
that is suitable for preclinical testing of antiretroviral therapy, vaccines, curative strategies …
that is suitable for preclinical testing of antiretroviral therapy, vaccines, curative strategies …
Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages
Simian immunodeficiency virus (SIV) infection of rhesus macaques causes immune
depletion and disease closely resembling human AIDS and is well recognized as the most …
depletion and disease closely resembling human AIDS and is well recognized as the most …
Differential outcomes following optimization of simian-human immunodeficiency viruses from clades AE, B, and C
LJ Tartaglia, S Gupte, KC Pastores, S Trott… - Journal of …, 2020 - Am Soc Microbiol
Simian-human immunodeficiency virus (SHIV) infection of rhesus monkeys is an important
preclinical model for human immunodeficiency virus type 1 (HIV-1) vaccines, therapeutics …
preclinical model for human immunodeficiency virus type 1 (HIV-1) vaccines, therapeutics …
[HTML][HTML] Infection pressure in apes has driven selection for CD4 alleles that resist lentivirus (HIV/SIV) infection
CJ Warren, A Barbachano-Guerrero, VL Bauer… - eLife, 2024 - elifesciences.org
Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
[HTML][HTML] Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner
A Sharma, RN McLaughlin Jr, RS Basom… - PLoS …, 2019 - journals.plos.org
HIV-1 does not persistently infect macaques due in part to restriction by several macaque
host factors. This has been partially circumvented by generating chimeric SIV/HIV-1 viruses …
host factors. This has been partially circumvented by generating chimeric SIV/HIV-1 viruses …