Elite control, gut CD4 T cell sparing, and enhanced mucosal T cell responses in Macaca nemestrina infected by a simian immunodeficiency virus lacking a gp41 …
MW Breed, SE Elser, W Torben, APO Jordan… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT Deletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking
signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus …
signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus …
Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host
LJ Demma, TH Vanderford, JM Logsdon, MB Feinberg… - Retrovirology, 2006 - Springer
Background The ability of emerging pathogens to infect new species is likely related to the
diversity of pathogen variants present in existing reservoirs and their degree of genomic …
diversity of pathogen variants present in existing reservoirs and their degree of genomic …
Signatures in simian immunodeficiency virus SIVsmE660 envelope gp120 are associated with mucosal transmission but not vaccination breakthrough in rhesus …
SA Smith, KM Kilgore, SP Kasturi, B Pulendran… - Journal of …, 2016 - Am Soc Microbiol
Mucosal surfaces are vulnerable to human immunodeficiency virus (HIV)/simian
immunodeficiency virus (SIV) infection and thus are key sites for eliciting vaccine-mediated …
immunodeficiency virus (SIV) infection and thus are key sites for eliciting vaccine-mediated …
The envelope cytoplasmic tail of HIV-1 subtype C contributes to poor replication capacity through low viral infectivity and cell-to-cell transmission
E Santos da Silva, M Mulinge, M Lemaire… - Plos one, 2016 - journals.plos.org
The cytoplasmic tail (gp41CT) of the HIV-1 envelope (Env) mediates Env incorporation into
virions and regulates Env intracellular trafficking. Little is known about the functional impact …
virions and regulates Env intracellular trafficking. Little is known about the functional impact …
Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent …
Background Lentiviruses such as human and simian immunodeficiency viruses (HIV and
SIV) undergo continual evolution in the host. Previous studies showed that the late-stage …
SIV) undergo continual evolution in the host. Previous studies showed that the late-stage …
Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists
G Lin, A Bertolotti-Ciarlet, B Haggarty… - Journal of …, 2007 - Am Soc Microbiol
Entry of human immunodeficiency virus type 1 (HIV-1) and HIV-2 requires interactions
between the envelope glycoprotein (Env) on the virus and CD4 and a chemokine receptor …
between the envelope glycoprotein (Env) on the virus and CD4 and a chemokine receptor …
Adapting SHIVs In Vivo Selects for Envelope-Mediated Interferon-α Resistance
Lentiviruses are able to establish persistent infection in their respective hosts despite a
potent type-I interferon (IFN-I) response following transmission. A number of IFN-I-induced …
potent type-I interferon (IFN-I) response following transmission. A number of IFN-I-induced …
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
RS Roark, H Li, WB Williams, H Chug, RD Mason… - Science, 2021 - science.org
INTRODUCTION It is widely believed that the development of an effective neutralizing
antibody–based HIV-1 vaccine will require consistent activation of multiple germline …
antibody–based HIV-1 vaccine will require consistent activation of multiple germline …
Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting …
The envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus
type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing …
type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing …
[HTML][HTML] Neutralization sensitivity of HIV-1 Env-pseudotyped virus clones is determined by co-operativity between mutations which modulate the CD4-binding site and …
S Beddows, NN Zheng, C Herrera, E Michael, K Barnes… - Virology, 2005 - Elsevier
Adaptation of antibody neutralization-resistant human immunodeficiency virus type I (HIV-1)
to growth in vitro generally results in the acquisition of a neutralization-sensitive phenotype …
to growth in vitro generally results in the acquisition of a neutralization-sensitive phenotype …