The development of a panel of mucosally transmissible simian-human immunodeficiency
virus (SHIV) challenge stocks from multiple virus clades would facilitate preclinical …

Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed
conformation and infrequently sample open states, limiting access to internal epitopes. Thus …

HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic
changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 …

Human immunodeficiency virus type 1 (HIV-1) is a chronically replicating lentivirus that must
escape from adaptive immune responses that arise during the course of infection. Viral …

Antibodies that can neutralize diverse viral strains are likely to be an important component of
a protective human immunodeficiency virus type 1 (HIV-1) vaccine. To this end, preclinical …

The high-affinity in vivo interaction between soluble HIV-1 envelope glycoprotein (Env)
immunogens and primate CD4 results in conformational changes that alter the …

The role of antibodies directed against the hyper variable envelope region V1 of human
immunodeficiency virus type 1 (HIV-1), has not been thoroughly studied. We show that a …

The monoclonal antibody (MAb) VRC01 was isolated from a slowly progressing HIV-1-
infected donor and was shown to neutralize diverse HIV-1 strains by binding to the …

ABSTRACT A rare but natural polymorphism in the HIV-1 envelope (Env) glycoprotein,
lysine at position 425 was selected as a mutation conferring resistance to maraviroc (MVC) …

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1
(HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or …