While the pathogenesis of Parkinson's disease (PD) is incompletely understood,
mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we …

Due to environmental insult or innate genetic deficiency, protein folding environments of the
mitochondrial matrix are prone to dysregulation, prompting the activation of a specific …

Mitochondria are highly dynamic, multifunctional organelles. Aside from their major role in
energy metabolism, they are also crucial for many cellular processes including …

Eur J Clin Invest 2010; 40 (11): 1048–1060 Abstract Impaired mitochondrial function has
been implicated in neurodegeneration in Parkinson's disease (PD) based on biochemical …

Neurons are metabolically active cells with high energy demands. Thus, neurons are
particularly reliant on mitochondrial function, especially on the homeostasis properties of …

Mitochondrial impairment is a well-established pathological pathway implicated in
Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain …

Parkinson's disease (PD) is a progressive neurodegenerative disease and is characterized
pathologically by selective loss of nigrostriatal dopaminergic neurons and the formation of …

Parkinson's disease (PD), the most frequent movement disorder, is caused by the
progressive loss of the dopamine neurons within the substantia nigra pars compacta (SNc) …

Parkinson's disease (PD) is a complex multifactorial disorder where environmental factors
interact with genetic susceptibility. Accumulating evidence suggests that mitochondria have …

Parkinson's disease (PD) is the second most common neurodegenerative disease, which is
characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta …